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Disulfiram/Copper complex improves the effectiveness of the WEE1 inhibitor adavosertib in p53 deficient non-small cell lung cancer via ferroptosis

* Figure adapted from reference.67 A greater frequency of mitochondrial polymorphisms (16519T and 3010A) has recently been identified in pediatric patients with CVS, compared with controls,1618 but it was not found in Asian pediatric populations or in adults.19,20 This variability may be due to the small sample sizes, involuntary bias during patient recruitment, and the differences in allelic frequencies between the different ethnicities

Factors that deplete glutathione include: Trauma Aging Medications Chronic stress Chemical pollutants Environmental Toxins Radiation Poor diet Considering the stressful, polluted world we live in, it is not surprising that many people become glutathione deficient

More intriguing, Gabor et al