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Disruptions in lipid metabolism were also evident in EP

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Endothelial impairment increases the expression of adhesion molecules, attracting circulating immune cells, particularly monocytes, to the endothelial surface

The CPS is thought to be a major virulence determinant, with initial studies using subtractive hybridisation, demonstrating that a CPS I-mutant had an LD 50 similar to that of B