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This explains why the inhibitory effect of PHGDH suppression on breast cancer cell proliferation is unlikely to be rescued by the supplemented extracellular serine

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For instance, transcription factors like NF-B, signal transducer and transcription activator (STAT) and activator protein-1 (AP-1) regulate the expression of the genes which control cellular proliferation, survival, metastasis, invasion, transformation, programmed cell death, adhesion, and angiogenesis (Gupta et al., 2010)