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Circadian disturbances are not likely to be an epiphenomenon of bipolar illness given that they are present during mania, depression, in euthymic state, and in healthy relatives of bipolar patients (181, 182)

H 2 S can react with oxidized thiol (sulfenic acid) compounds, including protein thiols, to yield persulfides, which have higher nucleophilicity than the corresponding monosulfides 31