glutathione s transferase flavone Frontiers Glutathione-S-Transferases as Potential Targets for

Ubiquitin-proteasome inhibition enhances apoptosis of human pancreatic cancer cells Surgery 1999 126 : 371377 Sumitomo M, Tachibana M, Ozu C, Asakura H, Murai M, Hayakawa M, Nakamura H, Takayanagi A, Shimizu N

In chronic myelocytic leukemia (CML), inhibition of the MUC1-C oncoprotein disrupts redox balance and thereby 1) decrease break-point cluster region protein (BCR)/Tyrosine-protein kinase (ABL) levels, 2) downregulate -catenin expression, and 3) induce terminal myeloid cell differentiation, thus avoid CML to enter the acute phase[47]

Yet, these potential benefits of isothiocyanates in cancer therapy have not been explored in clinical trials (72)

F.RegevA