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T., Chan, C

High levels of UCPs may lead to high levels of protein leakage and uncoupling of substrate oxidation from ADP phosphorylation, thereby limiting ATP synthesis and energy loss ( Besides, APS may promote mitochondrial biogenesis through the AMPK-mediated peroxisome proliferator-activated receptor coactivator 1 (PGC-1)/nuclear factor erythroid 2-like 1 (NRF1) signaling pathway, up-regulating the mitochondrial transcription factor A level to improve mitochondrial oxidative phosphorylation levels and boost mitochondrial function and mitochondrial DNA replication (Kan, 2018