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This improvement in mitochondrial function is facilitated by activating key pathways such as SIRT1/PGC-1, critical for enhancing mitochondrial DNA replication and transcription, both essential processes for efficient cellular energy production [93, 94]

Standardization of protocols, patient stratification, and integration with disease-modifying therapies will be critical for translation into clinical practice

Fine mapping of critical transcription factors and their authentic binding sites within the Hdc promoter and enhancers should promote identification of regulatory variants that influence allergy susceptibility and severity

Eh-Haj BM