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The realm of medicine is constantly evolving, and the incorporation of needle less injection technology is a testament to this progression

Acknowledgments The authors thank professor Haibo Mu who provided helpful comments for revising the paper

Although the data are mixed with some studies demonstrating no effect of supplemental vitamin D and/or Ca on bone health (76, 77) there are several well-controlled clinical trials and meta-analyses suggesting there is a synergistic relationship between intake of Ca and vitamins D and K on markers of bone health (i.e., bone mineral density, circulating levels of biomarkers associated with bone health, and risks of fractures) (4447, 78)