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In the folate cycle, folic acid is reduced by dihydrofolate reductase (DHFR) to the biologically active tetrahydrofolate (THF) (Newman and Maddocks, de novo ATP synthesis powered by the folate cycle directly contributes to the formation of SAM, a critical donor to multiple methylation reactions (Maddocks et al., de novo generation of ATP by the folate cycle is likely to be indispensable in maintaining energetic homeostasis, particularly in conditions of high energy demand such as sustaining high rates of proliferation

[DOI] [PubMed] [Google Scholar] PubMed, 2006