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Danazol, a weak androgen that inhibits gonadotropin secretion, resulting in decreased serum testosterone levels, has been studied in a prospective placebo-controlled trial, whereby gynecomastia resolved in 23 percent of the patients, as opposed to 12 percent of the patients on placebo (67)

8 film-coated tablets Dispense enclosed Medication Guide to each patient Karyopharm Therapeutics Principal Display Panel 100 mg (Once Weekly) Blister Sleeve Label NDC 72237-103-15 Rx ONLY 1 PRESS & HOLD HERE 100 mg Once Weekly Blister Pack 1

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Preserving CI function with NDI1 expression maintained adipogenic and lipogenic transcription in adipocytes lacking the circadian clock