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These nanosystems are designed to enhance drug encapsulation efficiency, enable controlled and sustained release, prolong systemic circulation, and facilitate tissue-specific accumulation through passive (e.g., enhanced permeability and retention effect) and active targeting mechanisms, such as ligand-mediated endocytosis [15, 16]

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Notably, other banned substances from the S4.1 group, such as aminoglutethimide, arimistane, formestane, or testolactone, may also be present in illegal samples purchased by athletes

Specifically, this protein corona can trigger the capture of nanoparticles by macrophages, thereby reducing the biological half-life