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In HCT8 cells, cystine transport activity was significantly inhibited by glutamate (Figure 8), indicating the occurrence of system x c in these cells, although the resistant variant (HCT8DDP) had a much higher activity of this system

Furthermore, to design effective stabilizing mutations that make these metastable proteins amenable for vaccine and antiviral development, more high-resolution structures of prefusion gB are required

The BRET signal increases in response to decreasing amounts of cAMP as a result of conformational changes in the sensor

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