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Aging can be defined as a progressive and irreversible decline in physiological integrity, driven by the accumulation of stressor-mediated damage and subsequent dysfunction at the cellular, tissue, and organ level [4]

As understanding of PCOS evolves, IR is increasingly recognized as a key factor in the pathogenesis of the disorder, resulting in the widespread utilization of metformin, a medication that enhances insulin sensitivity, for the management of PCOS

It is important to note that S1P is considered a tumor-promoting lipid due to its impact on autophagy, and increased S1P levels have been identified as a drug-resistance mechanism in some cancer types

Histamine receptors, agonists, and antagonists in health and disease