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[2] However, elevated MMA is not conclusive, as it is seen in people with B 12 deficiency, but also in elderly people who have renal insufficiency, [28] and elevated homocysteine is not conclusive, as it is also seen in people with folate deficiency

Typical daily range: 2.55 mg once or twice daily (subcutaneous)

Excessive methyl supplementation taking too much methylfolate or methyl-B12 for your needs COMT mutations slow breakdown of neurotransmitters, causing buildup when you add more methyls Histamine issues methylation can increase histamine in some people

In a Swiss study (11), almost half of all general practitioners agreed with prescribing B12 for unexplained fatigue, even though theres not much research to bear it out