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[PubMed] [Wolters] Kennedy RH, Owings R, Shekhawat, N, Joseph, J

Hepatotoxicity caused by APAP overdose is one of the leading causes of acute liver failure (ALF) in the US and in some parts of Europe, limiting its clinical application

Clinical translation of the developed PLGA-based nanosystems encapsulating conventional drugs and/or bioactive phytochemicals remains a challenge due to limited clinical trials validating the safety and efficacy of PLGA nano-systems

The following conditions for the ion transfer were used: 4500 V capillary voltage, 500 V endplate offset, 4 L/min dry gas at 200 C, 1.8 bar nebulizer pressure and 10 eV collision energy