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Bioorganic & Medicinal Chemistry, 26(10), 2700-2707

Accumulating evidence further demonstrates that in pSS models, reduced gut microbiome diversity and diminished production of microbiota-derived metabolites lead to decreased tolerogenic dendritic cells (DCs) and Th17/Treg imbalance, consequently promoting autoantibody accumulation and exacerbation of glandular inflammatory responses in pSS (203)