that compete with one or more of M25ADLF, M25ADLFEG, M25ADLFDS, M25FYIA, M25FYIAEG, M25FYIADS, M25, M25EG, M25DS, M25AELF, M25AELFEG, M25AELFDS, M25ADL99P, M25ADL99G, M25ADS95R, M25ADD28G, M25ADS91 G, M25ADY93H, M25ADYHSRLF, M25GRITSGFYGDwtLC, M25FSITSGFYGDwtLC, M253018IA, M253018LF, M25AD, M25ADX, ALPPL2rd3_l, ALPPL2rd3_2, M25AGIA, M25AGLF, M25 ASIA, M25ASLF, M25 ASwt, M25 AVIA, M25AVLF, M25 ALIA, M25ALLF, M25wtIA, and/or M25wtLF antibodies for binding to ALPP and/or ALPPL2 and/or to a cell expressing or overexpressing ALPP and/or ALPPL2, and/or by modification of the M25ADLF, M25ADLFEG, M25ADLFDS, M25FYIA, M25FYIAEG, M25FYIADS, M25, M25EG, M25DS, M25AELF, M25AELFEG, M25AELFDS, M25ADL99P, M25ADL99G, M25ADS95R, M25ADD28G, M25ADS91G, M25ADY93H, M25ADYHSRLF, M25GRITSGFYGDwtLC, M25FSITSGFYGDwtLC, M253018IA, M253018LF, M25AD, M25ADX, ALPPL2rd3_l, ALPPL2rd3_2, M25AGIA, M25AGLF, M25ASIA, M25ASLF, M25 ASwt, M25 AVIA, M25AVLF, M25 ALIA, M25ALLF, M25wtIA, and/or M25wtLF antibodies identified herein to produce libraries of modified antibody and then rescreening antibodies in the library for improved binding to cells expressing or overexpressing ALPP and/or ALPPL2 or a domain thereof
10.1016/j.mvr.2023.104510 Kay P, Yang YC, Hiscott P, Gray D, Maminishkis A, Paraoan L: Age-related changes of cystatin C expression and polarized secretion by retinal pigment epithelium: potential age-related macular degeneration links
Each haemoglobin molecule has a tetrahedral 3D structure with four haem (immature haemoglobin) groups surrounding a globin (protein) group ( Figure 1 )
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