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Ethics declarations Conflict of interest The authors declared no potential conflicts of interest with respect to the research, authorship, and publication of this article

Parnis FX, Coleman RE, Harper PG, et al

Second, some tumours may increase proteins that bind to B12 in the blood

Therefore, by first using the Trx system and then sequentially treating SNO-modified proteins with GSH, complete denitrification of S -nitrosothiol can be achieved, suggesting that the substrate selectivity of GSH and Trx systems for SNO-modified proteins is different [57]