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[3][4] Takeaway: next-gen trials should pair tumor-intrinsic drugs with TME-aware tacticsand measure spatial, immune, and microbial signals up front

Conversely, controlled enhancement of fatty-acid oxidation [e.g., via peroxisome proliferator-activated receptor alpha (PPAR) signaling] can sometimes rescue T cell energetic capacity in low-glucose settings, highlighting a context-dependent, bidirectional role of lipid metabolism [139]

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