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Second, pharmacokineticpharmacodynamic integration should be improved by reporting systemic exposure parameters alongside functional and structural neuropathy endpoints, including, where feasible, peripheral nerve or dorsal root ganglion concentrations

The inherent complexity of TCM formulations necessitates an unwavering commitment to ensuring batch-to-batch consistency, stability of active constituents, and safety through the development and stringent enforcement of comprehensive quality standards and Good Manufacturing Practices (GMP)

However, existing studies primarily focus on short-term intervention effects at the cellular and animal levels, with a notable absence of comprehensive long-term behavioral assessments and safety evaluations

Environ Sci Pollut Res 27:3269532706 Faria JMS, Teixeira DM, Pinto AP, Brito I, Barrulas P, Alho L, Carvalho M (2020) Toxic levels of manganese in an acidic Cambisol alters antioxidant enzymes activity, element uptake and subcellular distribution in Triticum aestivum