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Matrix metalloproteinases (MMPs) are up-regulated by pro-inflammatory cytokines, as well as by acute phase proteins like serum amyloid A (SAA), with counter-regulatory inhibition by IL-4 and IL-13, and released into the circulation from damaged vascular endothelium

treatment part 3, ongoing strategy for refractory status epilepticus treatment part 3, ongoing strategy for refractory status epilepticus Control of refractory and super-refractory status epilepticus in the ICU involves a recursive series of steps as described below