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doi: 10.1007/s40257-014-0107-3, PMID: [DOI] [PubMed] [Google Scholar] 7.Degnan PH, Taga ME, Goodman AL

A review study proposed another mechanisms underlying the potential interaction of the smoking and oestrogen metabolites such as decrease in oestrogen activity, SHBG levels, aromatase enzyme activity, C-20, 22 desmolase enzyme levels and increase in free testosterone levels, hyperandrogenism and the hepatic metabolism of steroid (Reference Ruan and Mueck41)