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3.4 As tolerance through improved antioxidant defense system and reduced uptake A surplus of ROS, such as superoxide radicals (O2 + ), hydrogen peroxide (H 2 O 2 ), and hydroxyl radicals (OH), is produced when toxic substances are present in plants, leading to oxidative stress (124)

Lancet (london, England) 364(9437):875882

Individual animals with PPI-based evidence of NIT were subsequently treated with either NHPN-1010 or saline, wherein intervention was deliberately initiated four weeks (wks) after exposure

In the medulla, an elevated UA concentration results in the deposition of urate precipitates and the activation of the Nod-like receptor protein 3 (NLRP3) inflammasome