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14 Important differential diagnoses to consider include medication side effects (eg, methotrexate, chemotherapy, or antibiotics such as trimethoprim), and malabsorption due to an anatomic or autoimmune cause (pernicious anemia), as well as a primary bone marrow pathology such as myelodysplastic syndrome

Purity and dosing accuracy in commercially available capsule products are rarely verified by independent third-party testing, making formulation quality the single biggest practical variable

This paper explains current treatment strategies, including transfusion, chelation, and emerging therapies

It ages, loses elasticity, and suffers from oxidative stress and environmental damage