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A recent randomized, double-blind, placebo-controlled trial of low dose MTX in patients without known systemic rheumatic diseases showed that low dose MTX was associated with small to moderate risks of adverse events over a median follow-up of 23 months

Terushkin adjusted her treatment plan by recommending a slower dose escalation and suggesting dietary changes like smaller, more frequent meals

A provider who regularly walks new patients through their first mixing session often notices that the most common early mistake is drawing the liquid too quickly, which creates visible foam and makes the powder take far longer to fully dissolve