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COPD patients suffer from oxidative stress caused by the inhalation of cigarette smoke (CS) or harmful substances which causes an accumulation of pulmonary inflammatory cells (neutrophils, macrophages), leading to large numbers of reactive oxygen species (ROS)

Of the 6088 regulatory pairs we identified in transverse, 767 genemicrobiome regulatory pairs were tested due to the availability of significant eQTLs as IVs in the CEDAR data

The collected blood was centrifuged at 2,000 g for 25 min at 4C to separate serum samples, which were then stored at 80C