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Combination of metabolic inhibitors with immune checkpoint blockade: Pairing PD-1/PD-L1 or CTLA-4 inhibitors with agents targeting cancer cell metabolism (glycolysis, glutaminolysis) to simultaneously reduce metabolic competition and enhance checkpoint inhibitor efficacy

This design would permit head-to-head and placebo-controlled comparison within a biologically defined population, advancing mechanism-guided integration of botanical adjuncts into precision treatment frameworks for depression

Wjcik W, ukasiewicz M, Puppel K (2021) Biogenic amines: formation, action and toxicity a review

10.1111/mec.14890 47 CzajaR.JR.HolmbergR.Pales EspinosaE.HennenD.CerratoR.LwizaK.et al (2023)