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It is widely recognized that prolonged exposure to elevated levels of ROS can lead to oxidative DNA damage associated with a COSMIC (catalog of somatic mutations in cancer) mutation signature (Rose et al

The Specific P-Glycoprotein Inhibitor Tariquidar Is Also a Substrate and an Inhibitor for Breast Cancer Resistance Protein (BCRP/Abcg2)

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GGCT channels Gln flux for GSH synthesis and Glc anaplerosis into the TCA cycle ROS act as signaling molecules that regulate mitochondrial function, with mitochondrial morphology intrinsically linked to core processes, including the TCA cycle and oxidative phosphorylation