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Vitamin B12 deficiency and depression: What is the mechanism

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12 Alcohol and B12 absorption Chronic alcohol intake can damage the lining of the gastrointestinal system, significantly affecting the absorption of micronutrients, including B12

Moreover, quantification of myelinated axons in the lesion area showed a tendency to decrease the g-ratio of axons in leucovorin-, dyclonine-, and clemastine-treated animals compared to vehicle-treated controls, suggesting an increased remyelination (more wrapping) induced by the compound treatment, that reaches significance in the case of leucovorin treatment for axons larger than 1 m (Fig