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ROS-activated anticancer prodrugs: a new strategy for tumor-specific damage

doi: 10.1053/j.gastro.2020.05.051 42 Heltemes-HarrisLMFarrarMA

A., Horwitz, M

It is hypothesized that (1) lithium will protect neurons by increasing neuronal viability, dendritic length, and dendritic number, (2) lithium will increase the expression of BDNF gene and differentially regulate the expression of pro- and anti-apoptotic proteins, and (3) the effect of lithium on BDNF will be exon specific and will be epigenetically regulated