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The clinical presentation can vary widely depending on the type of mutation affecting SLC22A5 and the phenotypic manifestation of the mutation, i.e., age of onset, organ involvement, and severity of symptoms at the time of diagnosis (34)

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Volume 94

M0 macrophages, as resting or unpolarized macrophages, can differentiate into distinct subsets (M1 and M2) in response to alterations in the vascular microenvironment