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Calves (up to 1 year): 1mL/50 kg Cattle (1-2 years): 1mL/75 kg Cattle (over 2 years): 1mL/100kg Cows: 3 4 weeks before calving, mating and drying off Calves: At day 1 and weaning Heifers: Every 3 months, especially 3 4 weeks before mating Additional: Every 2 months in wet conditions WITHHOLDING PERIODS No withholding period is required when used as directed

This compound not only inhibited SARM1s NADase activity effectively but also exhibited a favorable safety profile, making it a strong candidate for further development 233

Martyn Hooper is the executive chair of the Pernicious Anaemia Society

They received 50, 150, or 300 mg canakinumab, or placebo as subcutaneous injections every three months for a median of 3.7 years