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7C, in the condition of exposing to PA, treatment HepG2 cells with the proteasome inhibitor MG132, GADD45 overexpression significantly increased SIRT1 protein expression levels compare with the control group, implicating that the UPS pathway may involve in this process

Some similar conditions are also there, which develop vitamin B12 deficiency in persons, such as Crohns disease or celiac disease

Due to the generally low intake of B12, supplement dosages must be significantly higher thus the daily requirement is covered only with supplements of approx