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Transcriptomic studies have characterized the compound as influencing the expression of a large number of genes, published analyses have reported effects on the expression of more than four thousand human genes, across the directional categories studied, with notable enrichment in pathways related to extracellular matrix remodeling, cellular proliferation, antioxidant response, and copper homeostasis

Unwanted weight and constant fatigue often go handinhand

1 The Overview of Nuclear Factor Erythroid (NF-E2)-Related Factor 2 (Nrf2) and Nuclear Factor-Kappa B (NF-B) 1.1 The Role of Nrf2 and Its Regulation When our body is continuously exposed to external stresses, its easy to produce the excessive free radicals and reactive oxygen species (ROS) in the mitochondria, peroxisomes, and endoplasmic reticulum (ER), and downregulate endogenous antioxidants such as enzymes and antioxidant proteins (may be stress upregulated sometimes, but not enough to resist oxidative stress), thereby leading to damage of cellular components including proteins, DNA, and lipids (Tonelli et al., 2018)

Oxidative stress is caused by high levels of toxic waste products known as reactive oxygen species or free-radicals