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Of all the B vitamins, folate has some of the strongest evidence for its use in treating depression : Some research studies have found that high-dose methylfolate may be as effective as some antidepressant medications

However, the exact dosage and frequency will be determined by a healthcare professional based on various factors such as your medical history, current health condition, and treatment goals

The medication is also useful to treat male infertility

Strengths of the current study include the large sample size, the detailed clinical assessment of depression and related characteristics, and the availability of the same data collected from participants still involved after 6 years of follow-up (totaling over 4,000 observations), which allowed further testing of the consistency of the detected associations