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[DOI] [PMC free article] [PubMed] [Google Scholar] Nho B., Lee J., Lee J., Ko K

GLP-1 receptor agonists work through multiple pathways : they suppress appetite through central brain effects, delay gastric emptying, and enhance glucose-dependent insulin secretion while suppressing glucagon

NNMT (nicotinamide N-methyltransferase) is upregulated in adipose tissue during obesity and metabolic dysfunction, where it actively depletes NAD+ by converting nicotinamide into N-methyl-nicotinamide for excretion

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