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Determinants of the increase in ketone concentration during SGLT2 inhibition in NGT, IFG and T2DM patients

Key facts from Pickarts original studies: GHK-Cu exists in the plasma of all healthy adults The concentration decreases with age , from ~200 ng/ml in 20-year-olds to ~80 ng/ml in 60-year-olds This decline correlates with the age-related loss of regenerative capacity of tissue Cu is essential for the biological activity, GHK without copper has a dramatically weaker effect These original observations launched a 50-year research program that today covers thousands of publications in dermatology, wound healing, ageing research and regenerative medicine

There has been a revival in the use of methylene blue (MB), together with artemisinin-based combinations, in the treatment of Plasmodium falciparum malaria, because MB also has a gametocytocidal action

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