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2.3 CIRT treatment To better illustrate the physical characteristics of the carbon-ion irradiation used in our in vitro setup, we have included a schematic representation of the dose and LET distribution across the irradiation field (Supplementary Figure S1)

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2.7 Cell culture and LPS-induced inflammatory model The human bronchial epithelial cell line BEAS-2B was cultured in BEGM Bronchial Epithelial Cell Growth Medium supplemented with the recommended growth factors and maintained at 37 C in a humidified atmosphere with 5% CO 2