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David Sinclair notes in his work: "NAD+ is pivotal for sirtuins and aging reversal

MYLK2 and MYLK3 are skeletal- and cardiac-specific MLCK-encoding genes, 153,154 respectively, while MYLK1 encodes long non-muscle isoforms (~210 kDa) including MLCK1 (full-length long MLCK) and MLCK2