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Whereas one study employing children with Down syndrome confirmed increased levels of uric acid and antioxidant capacity, in another study increased levels of uric acid were associated with increased oxidative stress markers, as documented by elevated allantoin, a major metabolic intermediate produced from uric acid (Tiano et al

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Together, in laboratory models, they assist the research of synergistic GH release mechanisms, pulsatile secretion patterns, and downstream IGF-1 signaling