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It enhances angiogenesis and upregulates vascular endothelial growth factor (VEGF), which increases blood supply to injured tissues

this may be especially important for IBD patients

Metformin has been shown to protect vascular ECs by enhancing autophagy flux and diminishing lipid accumulation (161).It attenuated the development of diabetes-accelerated AS by reducing Dynamin-related protein (Drp1)-mediated mitochondrial fission in an AMPK-dependent manner (162)

HDL from subjects with CHD also have decreased ability to prevent monocyte adhesion to endothelial cells and recruitment in arterial wall co-cultures, which could be associated with reduced PON1 levels amongst other cargo (845,873,874)