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While BCKDH and HACL1 are (as indicated above) TPP-dependent enzymes, their activity is rarely reported in the context of thiamine deficiency, with the majority of studies focusing on TKT and PDH or KGDH as indicators of oxidative stress (TKT) and mitochondrial dysfunction (PDH or KGDH)

GLP-1-based medications were initially developed to support blood sugar regulation

Furthermore, dysregulated glucose metabolism modulates tumor biology through multifaceted mechanisms, including remodeling the tumor microenvironment, deregulating signaling pathways, and facilitating immune evasion [53]

Research Article - (2018) Volume 7, Issue 4 Oun Al-iedani 1,2 , Karen Ribbons 2 , Rod Lea 2 , Saadallah Ramadan 1,2* and Jeannette Lechner-Scott 2,3,4 1 School of Health Sciences, University of Newcastle, Callaghan, NSW 2308 Australia 2 Hunter Medical Research Institute, Newcastle, Australia 3 Department of Neurology, John Hunter Hospital, Newcastle, NSW Australia 4 School of Medicine and Public Health, University of Newcastle, Callaghan, NSW Australia Corresponding Author: Saadallah Ramadan School of Health Sciences, Faculty of Health and Medicine University of Newcastle, Callaghan, NSW 2308 Australia Tel: +61240420573 E-mail: [email protected] Received Date: Nov 20, 2018