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However, the temporal dynamics of disease development remain poorly understood

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It has been shown that lower GI pressure is significantly elevated in patients with GERD compared to healthy subjects, which may be a major factor in the development of GERD ( Lactobacillus acidophilus and Bifidobacterium bifidum in promoting the migration of MMCs and facilitating small intestinal transit, lower GI motility ( 4.7 The products of microbiome (SCFAs) indirectly protect the esophagus from multiple pathways and have potential for the treatment of GERD Microorganisms in the colon are capable of fermenting indigestible food components and consuming prebiotics to produce short-chain fatty acids (SCFAs) ( Figure 2 )