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and reproductive, genetic, and environmental factors as well as lifestyle factors [31,32]

This can alleviate symptoms such as joint pain, muscle aches, and neurological issues, improving the quality of life for patients

Chawla LS, Bellomo R, Bihorac A, Goldstein SL, Siew ED, Bagshaw SM, et al

Ibuprofen, in particular, possesses Nf-kB inhibitory activity that may further help reducing excess inflammation/cytokine release in COVID-19 patients ( there is no evidence supporting the association between Ibuprofen and increased risk of severity of COVID-19 , a position strengthened by a systematic review appeared 2 months later ( Several studies are accumulating and reappraising the importance of NSAIDs in COVID-19 management ( in silico screenings independently identified the COX-II inhibitor celecoxib as a potential anti-SARS-CoV-2 drug, and a very recent study still under peer review reports its beneficial effects plus famotidine in hospitalized patients ( Despite this accumulating evidence, paracetamol (PAC) was suggested as a safer and recommendable alternative for the early and domiciliary management of pain and fever in COVID-19 patients