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In this context, nitric oxide and chemokines such as CC motif ligand 3 (CCL3), CCL4 and CCL5, which are secreted by reactive microglia, impair neuronal autophagy and countering these effects was found to be protective in disease models 33,81

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Twenty-eight participants were treated with a single unilateral IVT injection in four escalating doses, including 17 participants with a disease duration up to 1 year (eight of whom had unilateral disease) and 11 participants with chronic bilateral disease with a duration more than 1 year