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Drastic pH shifts can cause precipitation or denaturation

For the reasons presented in the sections above, this approach would exclude a significant fraction of patients for which serum vitamin B 12 does not reflect cellular, genetic, and pharmacological disturbances that lead to functional vitamin B 12 deficiency

Often associated with knee joint pathology

Choline supplementation promotes hepatic insulin resistance in phosphatidylethanolamine N-methyltransferase-deficient mice via increased glucagon action