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2.2 Intra-VLP nucleic acid encapsulation technologies While Section 2.1 Extra-VLP protein antigen display technologies detailed the spatial orchestration of surface antigens to dictate immune recognition, the interior lumen of the VLP offers a sequestered and shielded microenvironment for the encapsulation of functional nucleic acids, such as immunostimulatory CpG oligonucleotides or therapeutic mRNA

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The primary analysis was conducted using the Inverse Variance Weighted (IVW) method, and was further corroborated by an array of statistical techniques including MR-Egger, Weighted Median, Weighted Mode, cML-MA, ConMix, MR-RAPS, and DIVW to ensure robustness and reliability of the findings.Heterogeneity was evaluated using Cochrans Q test, horizontal pleiotropy was assessed through MR-Egger regression, and leave-one-out analyses were performed to validate the causal relationships