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15 Thus, a competition for selenium incorporation would be responsible for the decrease of the biosynthesis or activity of GPxs 1 and 3 leading to accumulation of H 2 O 2 that has been suggested to exert neurotoxic effects promoting oxidative stress and inflammation, which are critical factors of brain damage induced by cerebral ischemia

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In the OaGST structure, the bound GSH molecule forms hydrophobic interactions with Phe112 and Trp164 and two hydrogen bonds between His105 and Ser109 21

A potential route to reduce ischemia/reperfusion injury in organ preservation