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In general, it's safest to avoid taking NSAIDs if you have: Stomach ulcers or bleeding in your digestive system Kidney or liver disease Gastroesophageal reflux disease (GERD or chronic acid reflux) Crohn's disease or ulcerative colitis Diabetes that isn't yet under control High blood pressure that's hard to manage Bleeding disorders Heart failure A history of heart attack or stroke Pregnancy (or if you plan to get pregnant soon) You drink alcohol every day You have asthma that gets worse when you take aspirin You're 65 or older DMARDs for Psoriatic Arthritis Treatment If your psoriatic arthritis symptoms are mild to moderate or don't respond well to NSAIDs, your doctor may prescribe you a disease-modifying antirheumatic drug (DMARD)