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The same study revealed that inhibiting HMGB1 down-regulated Bcl-2 and MMP-2 but up-regulated Bax in gastric cancer cells [163]

#Oncology #CancerCare #NutritionEducation #ClinicalPractice #NutritionMatters To view or add a comment, sign in Insulin resistance leads to NAFLD When the body becomes insulin resistant,especially in the liver it leads to increased production of free fatty acids and excess lipid synthesis , causing fat to accumulate in the liver

Therefore, it has been observed that the antioxidant capacity found in the cellular matrix may become reduced in critical clinical conditions, including septic shock, cardiac bypass surgery, and reperfusion injury after organ transplantation, and renal dialysis [216]